Respiration and glycolysis of normal human lymphocytes.
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منابع مشابه
Respiration and Glycolysis of Normal Human Lymphocytes
By CARL J. HEDESKOV AND VIGc.o ESMANN T HE DETERMINATION of the respiratory and glycob tic activity of normal human lymphocytes from blood has been made possible by the recent development of methods for the separation of these cells from blood in sufficient numbers.12 Available reports show consistent results with respect to the rate of respiration,13 htmt threefold variations in glucose uptake...
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The effect of salicylate on the metabolism of peripheral blood lymphocytes in tissue culture was investigated. Lymphocytes incubated with sodium salicylate at a concentration of 30 mg/100 ml showed increased glucose consumption, lactic acid production, and oxygen consumption, evidence for uncoupling of oxidative phosphorylation. No decrease in cell number or viability (trypan blue dye exclusion...
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T HE RELATIVE CONTRIBUTIONS of gycolysis and respiration to energy production by normal leukocytes has been the subject of much study. Until recently it was generally believed that these cells depend primarily on glycolysis for their energy, since active respiration had relatively little effect on glucose catabolism, i.e., there was only a limited Pasteur effect.”2 The extensive studies of Luga...
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Addition of n-butyl nitrite to isolated rat hepatocytes caused an immediate glutathione depletion followed by an inhibition of mitochondrial respiration, inhi- bition of glycolysis and ATP depletion. At cytotoxic butyl nitrite concentrations, lipid peroxidation occurred before the plasma membrane was disrupted. Cytochrome P-450 inhibitors inhibited peroxynitrite formation and prev...
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With the technical assistance of Clarence Ellis M ANY DIVERGENT RESULTS have been published concerning the energy metabolism of human leukemic leukocytes. This subject has been extensively reviewed by Seelich.’ Leukemic lymphocytes have variously been reported to have low or absent aerobic glycolysis, low to high respiration, and low to high anaerobic glycolysis. Leukemic granulocytes have been...
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عنوان ژورنال:
- Blood
دوره 28 2 شماره
صفحات -
تاریخ انتشار 1966